Publications

Looser ZJ, Faik Z, Ravotto L, Zanker HS, Jung RB, Werner HB, Ruhwedel T, Möbius W, Bergles DE, Barros LP, Nave KA, Weber B and Saab AS. Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health. Nature Neuroscience 2024, doi: https://doi.org/10.1038/s41593-023-01558-3

Todorova V, Stauffacher MF, Ravotto L, Nötzli S, Karademir D, Ebner LJA, Imsand C, Merolla L, Hauck SM, Samardzija M, Saab AS, Barros LF, Weber B, Grimm C. Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation. Mol Neurodegener. 2023 doi: https://doi.org/10.1186/s13024-023-00602-x

Hösli L, Zuend M, Bredell G, Zanker HS, Porto de Oliveira CE, Saab AS, Weber B. Direct vascular contact is a hallmark of cerebral astrocytes. Cell Rep. 2022 doi: https://doi.org/10.1016/j.celrep.2022.110599

Hösli L, Binini N, Ferrari KD, Thieren L, Looser ZJ, Zuend M, Zanker HS, Berry S, Holub M, Möbius W, Ruhwedel T, Nave KA, Giaume C, Weber B, Saab AS. Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning. Cell Rep. 2022 doi: https://doi.org/10.1016/j.celrep.2022.110484

Glück C, Ferrari KD, Binini N, Keller A, Saab AS, Stobart JL, Weber B. Distinct signatures of calcium activity in brain mural cells. Elife. 2021 doi: https://doi.org/10.7554/eLife.70591

Passini FS, Jaeger PK, Saab AS, Hanlon S, Chittim NA, Arlt MJ, Ferrari KD, Haenni D, Caprara S, Bollhalder M, Niederöst B, Horvath AN, Götschi T, Ma S, Passini-Tall B, Fucentese SF, Blache U, Silván U, Weber B, Silbernagel KG, Snedeker JG. Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans. Nat Biomed Eng. 2021 doi: https://doi.org/10.1038/s41551-021-00716-x

Zuend M, Saab AS, Wyss MT, Ferrari KD, Hösli L, Looser ZJ, Stobart JL, Duran J, Guinovart JJ, Barros LF, Weber B., Arousal-induced cortical activity triggers lactate release from astrocytes. Nat Metab. 2020. doi: 10.1038/s42255-020-0170-4

Romanos J, Benke D, Saab AS, Zeilhofer HU, Santello M., Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol. 2019.
doi: 10.1038/s42003-019-0367-9

Baeza-Lehnert F, Saab AS, Gutiérrez R, Larenas V, Díaz E, Horn M, Vargas M, Hösli L, Stobart J, Hirrlinger J, Weber B, Barros LF.  Non-Canonical Control of Neuronal Energy Status by the Na+ Pump.  Cell Metab. 2019.
doi: 10.1016/j.cmet.2018.11.005.

Looser ZJ, Barrett MJP, Hirrlinger J, Weber B, Saab AS.  Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons.  Front Cell Neurosci. 2018.
doi: 10.3389/fncel.2018.00377

Saab AS, Nave KA. Myelin dynamics: protecting and shaping neuronal functions. Curr Opin Neurobiol. 2017.
doi: 10.1016/j.conb.2017.09.013

Stobart JL, Ferrari KD, Barrett MJP, Stobart MJ, Looser ZJ, Saab AS, Weber B. Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation.  Cereb Cortex. 2018.
doi: 10.1093/cercor/bhw366

Trevisiol A, Saab AS, Winkler U, Marx G, Imamura H, Möbius W, Kusch K, Nave KA, Hirrlinger J. Monitoring ATP dynamics in electrically active white matter tracts.  Elife 2017 
doi: 10.7554/eLife.24241

Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron 2016.
doi: 10.1016/j.neuron.2016.05.016.

Saab AS, Nave KA. Neuroscience: A mechanism for myelin injury. Nature 2016
doi: 10.1038/nature16865.

Mayrhofer JM, Haiss F, Haenni D, Weber S, Zuend M, Barrett MJ, Ferrari KD, Maechler P, Saab AS, Stobart JL, Wyss MT, Johannssen H, Osswald H, Palmer LM, Revol V, Schuh CD, Urban C, Hall A, Larkum ME, Rutz-Innerhofer E, Zeilhofer HU, Ziegler U, Weber B. Design and performance of an ultra-flexible two-photon microscope for in vivo research. Biomed Opt Express. 2015
doi: 10.1364/BOE.6.004228

Saab AS, Tzvetanova ID, Nave KA. The role of myelin and oligodendrocytes in axonal energy metabolism. Curr Opin Neurobiol. 2013
doi: 10.1016/j.conb.2013.09.008

Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013
doi: 10.1371/journal.pbio.1001604

Bai X, Saab AS, Huang W, Hoberg IK, Kirchhoff F, Scheller A. Genetic background affects human glial fibrillary acidic protein promoter activity. PLoS One. 2013
doi: 10.1371/journal.pone.0066873

Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F. Bergmann glial AMPA receptors are required for fine motor coordination. Science 2012
doi: 10.1126/science.1221140

Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave KA. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012.
doi: 10.1038/nature11007

Kolodziejczyk K, Saab AS, Nave KA, Attwell D. Why do oligodendrocyte lineage cells express glutamate receptors? F1000 Biol Rep. 2010.
doi: 10.3410/B2-57

Möbius W, Cooper B, Kaufmann WA, Imig C, Ruhwedel T, Snaidero N, Saab AS, Varoqueaux F. Electron microscopy of the mouse central nervous system. Methods Cell Biol. 2010,
doi: 10.1016/S0091-679X(10)96020-2

Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M. Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium. J Neurosci. 2009
doi: 10.1523/JNEUROSCI.3955-08.2009